Abstract:

Objective   To investigate the relationship between GPX1 gene Pro200Leu polymorphism and coronary artery disease (CAD).  Methods   A hospital-based case-control study was conducted on 375 premature CAD, 519 late-onset CAD patients and 334 controls with polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP)  to detect the polymorphism. Logistic regression models were performed to estimate the odds ratios (ORs) with 95% confidence intervals (CIs).  Results   The odds ratio of CT+TT versus CC genotype of Pro200Leu polymorphisms with CAD between early-onset CAD group and controls was statistically significant in multiple logistic model (OR: 1.96, 95%CI: 1.17-3.31). For the comparison between late-onset CAD group and controls, the odds ratio became nonsignificant after adjusting the potential confounders (OR: 1.75, 95%CI: 0.76-4.02).  Conclusion   T allele of GPX1 gene Pro200Leu polymorphism may be a risk factor in early-onset CAD.

Key words: Coronary artery disease;  Glutathione peroxidase 1 gene;  Polymorphism;  Oxidative stress