Abstract:

Objective     To evaluate the shortterm impact of allopurinol on arterial elasticity in the patients with hyperuricemia. Methods          59 cases of hyperuricemia, treated for 3 months, were randomly divided into allopurinol and control group. Blood pressure, blood glucose, lipids, hepatic and renal function, hsCRP, UA, brachialankle pulse wave velocity(baPWV) and anklebrachial index (ABI ) were observed before and after the treatment, and the side effects of the drug was also observed. Results   All patients accomplished the observation without serious side effects. In allopurinol group, systolic blood pressure (P<0.01), diastolic blood pressure (P<0.01), and hsCRP(P<0.05) were significantly lower than that of the control group. In allopurinol group, systolic blood pressure (P<0.01), diastolic blood pressure P<0.01), hsCRP(P<0.01)， UA(P<0.01), and baPWV(P<0.01) decreased significantly after the treatment.  In control group,  hsCRP(P<0.01), UA(P<0.01) decreased significantly after the treatment. Allopurinol and the decrease of hsCRP were independent impact factors for baPWV by multiple stepwise regression analysis. Conclusion     Allopurinol is safe and effective in the treatment of hyperuricemia, which can lower blood pressure and baPWV, improve blood vessel elasticity, and reverse early atherosclerosis. The decline in baPWV is associated with the improvement of inflamation state, which doesn′t depend on the change in UA.

Key words: Hyperuricemia; Allopurinol; Highsensitivity CRP; Brachialankle pulse wave velocity