JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (11): 79-83.

• Articles • Previous Articles     Next Articles

Expression and clinical significance of EP2 prostanoid receptor in
colon mucosa of ulcerative colitis

LI Mei1,2, GAO Yan-jing1, CUI Xiang-hua1， XU Yong-mei3   

  1. 1. Department of Gastroenterology， Qilu Hospital of Shandong University， Jinan 250012, China;
    2. Department of Gastroenterology, Zaozhuang Hospital, Zaozhuang Mining Group, Zaozhuang 277100, Shandong, China;
    3. The Outpatient department of the Chinese People’s Liberation Army Navy Submarine Academy,
    Qingdao 266071, Shandong, China
  • Received:2012-04-25 Online:2012-11-10 Published:2012-11-10

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Abstract:

Objective   To explore the relationship between EP2 and ulcerative colitis (UC) by detecting the expression of EP2 in mucosa of UC. Methods   27 patients with active UC, 11 patients with remissive UC and 23 normal control subjects were recruited into the trial. The ulcerative colitis disease activity index (UCAI) was used to calculate the pathological grade and disease stage. Expressions of EP2 were detected by the immunohistochemistry in colonic tissues of the patients and controls.  Results   The EP2 protein levels in colonic epithelial and inflammatory cells in the patients with active UC were higher compared with the patients with remissive UC and controls (P＜0.01). In the patients with active UC, EP2 expressions were positively related to the pathological grade.  Conclusion   Expressions of EP2 were significantly up regulated in the colon  mucosa of active UC patients and positively correlated with the inflammation degree，which indicates EP2 may be a new target for the UC treatment.

Key words: Ulcerative colitis; EP2 receptor; Immunohistochemistry

CLC Number: 

  • R574.62
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