Abstract:

Objective   To investigate the clinical value of Fibroscan stiffness measurement (FS) and ultrasonography (USG) in diagnosing chronic hepatitis B-related fibrosis.  Methods   114 chronic hepatitis B patients confirmed by the liver biopsy were detected through FS and USG. The USG parameters such as hepatic parenchyma, capsule, edge and vein were graded by the semi-quantitative score method. The liver biopsy pathology results were used as the golden standard to test the parameters of FS and USG through the receiver operating characteristic (ROC) curve.  Results   The parameters of FS and USG increased gradually with liver fibrosis exacerbation．And these parameters were well correlated with the pathological change on the liver fibrosis (r=0.81, 0.75, 0.73, 0.76, 0.76, and 0.80, P<0.001) . The ROC curve analysis showed that the areas under the curve for stiffness， the changes score of hepatic parenchyma, capsule, edge and vein and their total score were 0.89, 0.84, 0.84, 0.83, 0.81 and 0.86 respectively.  Conclusion   The parameters of FS and USG are well correlated with the liver fibrosis pathological change in chronic hepatitis B patients. FS has high sensitivity and specificity in diagnosing chronic hepatitis B-related fibrosis.

Key words:  Fibroscan; Transient elastography; Liver fibrosis; Ultrasonography; Liver cirrhosis， hepatitis B， Chronic