Abstract:

Objective   To observe and evaluate the clinical effect of structured management mode of premixed insulin therapy in patients with type 2 diabetes. Methods   In this study, 48 patients with type 2 diabetes were randomly assigned to two groups. They received premixed insulin subcutaneously twice a day and then were followed up for 16 weeks. Patients in the structured management intervention group received 9 times supervision and intensive education and management by specialized education nurse. While patients in the control group only received 6 times generally supervision and education. All patients were required to receive laboratory examination before and after the treatment, including HbA1c, fasting Cpeptide, 7-time points blood sugar spectrum, et al and fill in related questionnaire. Adverse reactions were also observed. Results   The levels of HbA1c and 7-time points blood sugar spectrum decreased in both groups, while were much lower in the structured management intervention group(P<0.01 or P<0.05). Behavior and cognitive significantly improved in the structured management intervention group compared to the control group. There were no significant differences of BMI and fasting C-peptide before and after treatment, also between two groups. Lower incidence of hypoglycemia was reported in the structured management intervention group(P<0.05). Conclusion    After the structured management intervention treatment, type 2 diabetes mellitus patients using the premixed insulin therapy have a better blood sugar control, a better behavior and cognitive change, and a lower risk of hypoglycemia.

Key words: Diabetes mellitus， type 2；  Structured management intervention；  Clinical effect；  Rating scale