JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (1): 122-.

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Polymorphisms of killer cell immunoglobulin-like receptor genes in patients with pulmonary tuberculosis

LU Chao1, SHEN Ya-juan1, DENG Yun-feng2, WANG Chang-yin1, ZHANG Bing-chang1, FAN Gang1, ZHAO Yue-ran3, LIU Yi-qing1, ZHAO Sheng-mei1, WANG Zi-e1, ZHANG Chun-zhi1, LU Zhi-ming1   

  1. 1. Department of Laboratory Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;
    2. Infection Office, Shandong Chest Hospital, Jinan 250013, China;
    3. Center for Science Research, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2011-06-07 Online:2012-01-10 Published:2012-01-10

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Abstract:

Objective   To investigate association of polymorphisms of killer cell immunoglobulin-like receptor(KIR) genes with susceptibility to tuberculosis (TB) infection. Methods   Sequence specific primer polymerase chain reaction (SSPPCR) method was used to analyze 14 KIR genes in genomic DNA in 30 smear-positive (SP) patients, 79 smear-negative (SN) patients and 30 healthy controls. Results   Frequencies of KIR2DL5 (P=0.007), 2DS1 (P=0.038), 2DS3 (P=0.010) and 3DS1(P=0.002) were statistically significantly higher in the SP group than in the control group, while KIR2DS5(P=0.038) was lower. Also, frequencies of KIR2DL5 (P=0.018), 2DS1 (P=0.000), 2DS5 (P=0.000) and 3DS1 (P=0.001) were significantly higher in the SN group than in the control group. Compared with the SN group, frequencies of KIR2DS4 (P=0.004) and KIR2DS5 (P=0.000) were higher in the SP group. In addition, the number of subjects carrying more than two activating KIR genes in TB group was higher than that in the control group (P=0.013). The frequency of genotype AJ was lower in TB patients than in the controls. Conclusion   Polymorphisms of KIR genes may be associated with susceptibility to TB infection.

Key words: Killer cell immunoglobulin-like receptor; Tuberculosis, Pulmonary; Polymorphism, single nucleotide

CLC Number: 

  • R521
[1] WANG Xin-jie1， DU Xiang-yang2. Combined detection of procalcitonin and adenosine deaminase
for tuberculous pleural effusion [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 79-82.
[2] XU Yong, HU Hua, CHI Jing-yu, YANG Yan, JU Yun-fei, HOU Bao-qing, LI Xue-zheng. Detection of SP-D in the serum from pulmonary tuberculosis patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(5): 125-.
[3] HU Hua， XU Yong， CHI Jingyu， JU Yunfei， YANG Yan， HOU Bao-qing， LI Xue-zheng， MENG Fan-min， LI Lei. Value of SP-D levels in the sputum in the diagnosis of pulmonary tuberculosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(9): 79-81.
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