Abstract:

Objective   To detect expressions of matrix metalloproteinases-9 (MMP-9) and interleukin-6 (IL-6) in pancreatic neoplasm, and to analyze the relationships between the two cytokines and clinical pathological classification. Methods   The immunohistochemical technique was used to explore expressions of MMP-9 and IL-6 in 50 cases of human pancreatic neoplasm and 20 cases of non-tumor pancreatic tissues, and the relationships between their expressions and the clinical pathological classification were analyzed. Results   Expressions of MMP-9 and IL-6 were significantly higher in pancreatic neoplasm tissue than in normal pancreatic tissues. Expressions of MMP-9 and IL6 were significantly higher in stagesⅢ-Ⅳ  than in stages Ⅰ-Ⅱ. In pancreatic neoplasm tissue, MMP-9 and IL-6 expression rates decreased with different degrees of differentiation (high, moderate and low). Conclusion   Expressions of MMP-9 and IL-6 in pancreatic neoplasm are increased, and high expressions may correlate with the occurrence and development of pancreatic carcinoma.

Key words: Pancreatic neoplasms; Matrix Metalloproteinases-9; Interleukin-6; Immunohistochemistry