Abstract:

Objective     To investigate the  usefulness of the plasma osmotic pressure score in predicting prognosis of patients with hepatorenal syndrome (HRS). Methods    A total of 106 patients enrolled in the study were divided into a survival group (30 cases) and a death group (76 cases) by the prognosis in  a 3-month follow-up. Five scores were performed: plasma crystal osmotic pressure score, plasma colloid osmotic pressure score, total plasma osmotic pressure  score (the two combined), model for end-stage liver disease (MELD) score and Child-Pugh score  and these  scores were compared in terms of reliability when used to predict the prognosis of HRS. Results    The  values  for the death group evaluated by all but the crystal osmotic pressure score were significantly higher than those for the survival group(P<0.01). The area under curve(AUC)values of the Child-Pugh score, the MELD score and the total plasma osmotic pressure score were  all above 0.7,  while those of the other two scores were both below 0.7.  The Youden′s indexes were in the order of  the total plasma osmotic pressure score＞the MELD score＞the Child-Pugh score. Conclusions     The total plasma osmotic pressure  score, the MELD score and the Child-Pugh score can  reliably predict prognosis of HRS patients, with the total plasma osmotic pressure score showing the best correlation with prognosis.

Key words: Hepatorenal Syndrome; Liver cirrhosis; Plasma osmotic pressure score; ChildPugh score; MELD score