Abstract:

Objective     To study the curative and preventive effects and the mechanism of huohuazengshi(HHZS) medicinalgranules on proliferative vitreoretinopathy(PVR) through establishing an experimental animal model of PVR. Methods     45 rabbits (45 eyes) were randomly divided into the model group, the joletion tablet group and the HHZS medicinalgranules group. Experimental PVR models were induced by injecting macrophages into the vitreous. Contents of MCP-1 and TGF-β2 in the vitreous humour were determined by ELISA. Then the rabbits were executed at days 3, 7, 14, 21 and 28. Results     Compared with the model group and the joletion tablet group, the content of MCP-1 in the HHZS medicinalgranules group was significantly decreased at day 7(P<0.01), while the content of TGF-β2 was increased at day 3 and reached the peak at day 14(P<0.01).  Conclusion     HHZS medicinalgranules could inhibit the formation and development of PVR by decreasing the content of MCP-1 and increasing the content of TGF-β2 in the vitreous at the inflammatory phase and early proliferative phase.

Key words:  Proliferative vitreoretinopathy; Huohuazengshi medicinalgranules; MCP-1; TGF-β2