JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2011, Vol. 49 ›› Issue (4): 150-153.

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Expressions of trefoil factors 1 and 2 and cyclooxygenase-2  in gastric carcinoma

SHI Lei1,  LAI Ming-yu1,  LIANG Zhi-hai2,  LIU Shi-quan2,  HUANG Jie-an2,  TANG Guo-du2,  JIANG Hai-xing2   

  1. 1. Department of Geriatric Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;
    2. Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
  • Received:2010-10-19 Online:2011-04-10 Published:2011-04-10

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Abstract:

Objective     To investigate expressions of trefoil factor 1 (TFF1) ,trefoil factor 2 (TFF2) and cyclooxygenase-2(COX-2) in the normal gastric mucosa, carcinoma-adjacent tissues and gastric carcinoma, and to explore their roles in pathogenesis of gastric carcinoma. Methods    Expressions of TFF1,TFF2 and COX-2 were determined by immunohistochemistry in 130 gastric specimens, including 30 specimens of normal gastric mucosa, 50 specimens of carcinoma-adjacent tissues and 50 specimens of gastric carcinomas. Results    In the normal gastric mucosa, carcinoma-adjacent tissues and gastric carcinoma, TFF1 and TFF2 expressions showed a decreasing tendency(P<0.01)), while the COX-2 expression showed an increasing tendency(P<0.01). Expressions of TFF1 and TFF2 were negatively related to that of COX2(P<0.01). Conclusion    The increase in expression of COX-2 inhibits expressions of TFF1and TFF2, and unbalance between proliferation and apoptosis of cells results in carcinogenesis. 

Key words: Trefoil factor 1; Trefoil factor 2; Cyclooxygenase-2; Gastric neoplasms; Immunohistochemistry

CLC Number: 

  • R573.9
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