Abstract:

Objective     To investigate expressions ,  significance and interaction of hTERT and P53 in colorectal carcinomas. Method     Expressions of hTERTand P53 were detected in 52 cases of tumor tissues and tumor-adjacent norma1 tissues by the immunohistochemical method of SABC. Results     The positive rate of hTERT in colorectal cancer was 80.8%(40/52) and in cancer adjacent normal tissues was 0%; The positive rate of P53 in colorectal cancer was 73.1%(38/52) and in cancer adjacent normal tissues was 0%. Over-expression of hTERT and P53 had no relation with gender,  age and tumor depth(P>0.05). but was significantly related to tumor differentiation,  lymph node metastasis,  and Dukes staging(P<0.05). hTERT and P53 expression was positively correlated(r=0.538, P<0.05）. Conclusion     hTERT and P53 participate in common pathways in tumor development，progression and metastasis，and may play an important role in colorectal carcinomas．

Key words: Colorectal carcinoma; hTERT；P53