Abstract:

Objective    To observe characteristic changes of true insulin secretion and ratios of true insulin to immunoreactive insulin(TI/IRI) in patients newly diagnosed as having type 2 diabetes mellitus(T2DM) before and after treatment with xiaoke pills or repaglinide.  Methods    90 patients with newly diagnosed T2DM were randomly divided into two groups: 44 patients in the xiaoke pills group, and 46 patients in the repaglinide group. After collecting fasting, 30min and 120min venous blood before and after treatment, blood glucose was measured with the glucose oxidase method, true insulin with ELISA and immunoreactive insulin with radioimmunoassay.  TI/IRI was calculated at various times. Results     120min TI/IRI in xiaoke pills group had an obvious increase after treatment compared with that before treatment［ (0.60±0.13) vs (0.53±0.14), P<0.05］, while 30 min TI/IRI had a minor increase(P＞0.05).  30min TI/IRI in the repaginate group had an obvious increase compared with that before treatment［(0.63±0.08) vs (0.44±0.17), P<0.05］.  Conclusions    The quality and quantity of true insulin secretion in 120 minutes have obvious improvement after treatment with xiaoke pills. The quality and quantity of true insulin secretion in 30 minutes have an obvious difference compared with treatment with repaglinide.

Key words: Type 2 diabetes mellitus; Xiaoke pills; True insulin; True insulin/immunoreactive insulin