Abstract:

Objective   To investigate the therapeutic effect of different thrombolysison on acute deep venous thrombosis (DVT) . Methods   Twenty-eight patients with acute DVT were randomly divided into the control group(n=14) and the experimental group (n=14). After inferior vena cava filter(IVCF) placement, patients in the control group received systemic thrombolysis and anticoagulation therapy, while patients in the experimental group underwent anticoagulation therapy and catheter-directed thrombolysis. Circumferences of the limbs were measured before and after treatment. The thrombolytic level was evaluated by venography. Recent complications of interventional therapy and the occurrence of pulmonary embolism (PE) were observed. Results   The differentials were both reduced in circumferences of healthy and affected lower extremities after treatment. The resolution time of swelling in affected extremities was shorter in the experimental group than in the control group (P<0.01) . The thrombi completely disappeared in 5 patients(35.71%). The resolution time of thrombi was shorter in the experimental group than in the control group(P<0.01) . The mean dose of urokinase used in the experimental group was (1. 56 ±5. 80) ×106U, which was significantly lower than (3.06±8.24)×106U in the control group (P<0.01). In the control group, grosshematuria w and displacement of IVCF occurred in 1 patient. PE did not occurred in either group. Conclusion   IVCF placement and catheter-directed thrombolysis is a safe and effective procedure for acute DVT in the lower extremities.

Key words: Inferior vena cava filter； Deep venous thrombosis； Catheter-directed thrombolysis；  Plmonary embolism； Post thrombotic syndrome