Abstract:

Objective     To investigate the clinical value of fibroscan (FS) in the diagnosis of hepatitis B related fibrosis. Methods     Stiffness, hyaluronic acid(HA), laminin(LN), propeptide type Ⅲ of procollagen (PⅢP) and collagen Type Ⅳ(CV-IV) were detected in 59 chronic hepatitis B patients having undergone liver biopsy. The diagnostic values of FS and serum liver fibrosis markers were tested by the receiver operating characteristic (ROC) curve, using liver biopsy as the  gold standard. Results    In patients with moderate or serious fibrosis, the stiffness value was significantly high, and correlated with the fibrosis degree （r=0.76, P=0.00）.The ROC curve analysis showed that the areas under the curve for stiffness, HA, LN, PⅢP and CV-IV were 0.98, 0.82, 0.74, 0.59 and 0.76 respectively. The sensitivity and specificity for  stiffness were higher than those with serum liver fibrosis markers. Conclusion    FS is an effective method in the diagnosis of hepatitis B related fibrosis.

Key words: Liver elastography； Liver fibrosis； Liver cirrhosis；  Hepatitis B, chronic