Abstract:

Objective    To observe the efficacy and safety of Biapenem in the treatment of Anthonisen I and mechanical ventilation will be demanded in acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods     A control study of Biapenem (the treatment group) and imipenem-cilastatin (the control group) in the treatment of 68 patients was carried out．The C-reactive protein levels were measured on admission, and on day 3 patients with a decline of <50% in CRP levels in the two groups were compared. Results    The total effective rates of Biapenem and imipenem-cilastatin were 90.6.3％ and 86.1％ and bacterial clearance rates were 90.3 and 78.3％, respectively. An obvious decrease of CRP level was found in 3 days, but patients with a decline of <50% in CRP had no obvious difference between the two groups. Serious adverse effect was not seen. Conclusion     Biapenem is effective and safe in treating patients with Anthonisen I and mechanical ventilation will be demanded in AECOPD and has good bacterial clearance rates.

Key words: Pulmonary disease, obstructive; C-reactive protein; Biapenem