JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (9): 100-103.

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Expressions of estrogen receptor, progesterone receptor and c-erbB-2and their relationship with prognosis in breast carcinoma tissues

XU Yue-juan, QIU Shao-min   

  1. Department of Oncology, Nanjing Second Hospital, Nanjing 210003, China
  • Received:2010-05-13 Online:2010-09-16 Published:2010-09-16

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Abstract:

Objective     To study expressions of estrogen receptor(ER)，progesterone receptor(PR) and c-erbB-2and to explore their relationship with prognosis in breast carcinoma tissues. Methods    The immunohistochemical SP method was used to detect expressions of c-erbB-2, ER and PR from 193 breast carcinoma tissues. Results    Expression rate of c-erbB-2, ER and PR was 40.9%, 62.0% and 58.0%, respectively. Positive expression rate of c-erbB2 was correlated with tumor histological stage, clinical stage, and axillary lymph node metastasis. The total five-year survival rate was lower in the positive expression of cerbB2 group than in the negative group. Expression of ER had positive correlation with PR（P﹤0.01）. The positive expression of c-erbB-2 had negative correlation with ER and PR（P﹤0.05）.Conclusion     Detecting expressions of c-erbB-2, ER and PR gene in breast carcinoma tissues has an important role for leading clinical therapy and determining prognosis of breast carcinoma patients．

Key words: Breast carcinoma; Estrogen receptor; Progesterone receptor; c-erbB-2; Prognosis

CLC Number: 

  • R737.9
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