Abstract:

Objective    To observe the effect of AAP, a Chinese herbal compound, on the behavior and growth of mice with seizures induced by pentetrazole (PTZ). Methods    Sixty healthy mature male Kunming mice were randomly divided into 6 groups (n=10 in each group): the control group (CK group), the model group (PTZ group), three AAP groups with large, medium and small doses (AAPl group, AAPm group and AAPs group), and sodium valproate group (VPA group). The control group and model group were given intragastric administration of distilled water (4mL/kg·d)； the three AAP groups were given intragastric administration of AAP at doses of 14.8g/kg ,7.4g/kg and 3.7g/kg respectively； and the VPA group was given intraperitoneal injection of sodium valproate (20mg/kg·d). After 7 days of treatment, the seizure was induced by intraperitoneal injection with pentylenetetrazol（95mg/kg）in all groups other than the control group. Behavioral observation was conducted with Yuhas 5grade assessment during the establishment of the models, and the weight gain values were recorded. Results    Compared with the model group, the latent period was prolonged and time span of the seizure was reduced in the AAPs group (both P＜0.05).The weight gain value in all the three AAP groups increased significantly (P＜0.05) compared with that in the VPA group. Conclusion    AAP can extend the latency, reduce the duration of epileptic seizures induced by PTZ, and increase the weight gain, so it has a positive anticonvulsant effect on mice.

Key words: Epilepsy; Models, animals; Chinese herbal compound; Latent period; Time span of the seizure; Weight gain