Abstract:

Objective    To explore the inbibitory effect of Azelnidipin on left ventricular hypertrophy in spontaneous hypertension rats(SHRs).  Methods    Twenty healthy SHRs were randomLy divided into the Azelnipin treatment group and the SHR group．At the same time，ten WKY rats( the WKY group) served as the normal control group. Rats in the Azelnidipin group were treated with Azelnidipin for 10 weeks and rats in the SHR and WKY groups were treated with 0.9％ NaCl of the same volume simultaneously. Ten weeks later, SBP, HR and the indexes of LVW／BW, TNF-α and NO were determined. Results    Compared with the WKY group,  SBP, LVW／BW and TNF-α of the SHR  groups had a great increase（P＜0.05）, and meanwhile NO in the serum and myocardium decreased（P＜0.05）. Compared with the SHR group, SBP, LVW/BW and NO in the serum and myocardium of the Azelnidipin group significantly increased（P＜0.05）, while TNF-αdecreased（P＜0.05）. Conclusion     Azelnipin may inhibit left ventricular hypertrophy of SHR, which may be related to the increase of NO and decrease of TNFα.

Key words: Azelnipin; Spontaneous hypertension; Rats; Tumor necrosis factor-alpha