JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (7): 91-94.

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Correlation between ALDH2 polymorphism and coronary slow flow phenomenon

LI Yong，  CHEN Yuguo， XU Feng， JI Wenqing， HAO Panpan， WEI Shujian   

  1. Department of Emergency, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2010-03-31 Online:2010-07-16 Published:2010-07-16

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Abstract:

Objective    To explore the correlation between aldehyde dehydrogenase 2(ALDH2) polymorphism and coronary slow flow phenomenon(CSFP). Methods    36 patients with coronary slow flow and 23 patients with normal coronary flow were enrolled, which were defined according to the TIMI frame count (TFC). Genotypes, TFC and clinical data of patients were determined. Results    Age level of patients in the slow flow group was significantly lower than that in the normal flow group ［(51.94±9.07) years vs (59.36±8.81) years, P﹤0.05］, while the other basic clinical data were similar between the two groups(P>0.05). The ALDH2 gene mutation rate was higher than in the normal flow group (χ2= 4.58, P=0.03). Logistic regression analysis showed further that the ALDH2 gene mutation was an independent risk factor for CSFP. Conclusion    The ALDH2 gene mutation may increase the incidence of coronary slow flow phenomenon.

Key words: Coronary slow flow phenomenon； Aldehyde dehydrogenase 2； TIMI frame count； Age

CLC Number: 

  • R541.4
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