JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (5): 97-100.

• Articles • Previous Articles     Next Articles

Exprlssions of CD49d and CD11b on CD56brightCD16- NK cell of early pregnancy

HUANG Xianliang1, DONG Baihua1, HU Weixu2, WANG Qingjie2, SONG Bingfeng2, WANG Chune2,LIU Jia2, KONG Beihua1, QU Xun2   

  1. 1. Department of Gynaecology and Obstetrics; 2. Institute of Clinic and Basic Medicine Research,
    Qilu Hospital of Shangdong University, Jinan 250012, China
  • Received:2010-01-20 Online:2010-05-16 Published:2010-05-16

PDF (PC)

479

Abstract:

Objective  To investigate the expressions of integrinα4（CD49d）and integrinαm (CD11b) on CD56brightCD16- NK cell of the peripheral blood and decidua in early pregnant women and the peripheral blood in missed abortion women. Methods  Peripheral blood samples were collected from early pregnant and missed abortion female, and uNK cells were isolated from the fresh decidua of early pregnant females by mechanical trituration and Ficoll gradient centrifugation. The fluorescent intensity of the integrines was detected by FCM. Results  Expressions of CD49d and CD11b on CD56brightCD16- NK cell of peripheral blood in early pregnant women those higher than were in the first trimester decidua( P＜0.01), and also higher than those in missed abortion women (P＜0.05). Conclusion  CD49d and CD11b may play an important role in the recruitment of uNK cells and participates in the maintenance of normal pregnancy.

Key words: Early pregnancy; Missed abortin; uNK cell; Integrin

CLC Number: 

  • R714.14
[1] YIN Xian-ming1, DONG Bai-hua1, ZHANG Yun2, SU Shi-li1, DONG Zhao-gang2, QU Xun2. Expression of integrin αvβ3 on NK cells of women with  early pregnancy or missed abortion [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 140-.
[2] ZHANG Yun 1,2, SUN Jin-tang 2, HUANG Xian-liang 3, YANG Mei-xiang 2,SHAO Qian-qian 2, DENG Bi-ping 2, XU Xiao-fei 3,MAO Hai-ting 2, DONG Ba. Heterogeneity of human peripheral and decidual monocytes of women in early pregnancy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(3): 98-101.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd