Abstract:

Objective  To investigate the association between the tumor necrosis factor receptor Ⅱposition 196 (TNFRⅡ196) gene polymorphism and patients with rheumatoid arthritis (RA).  Methods    We performed a metaanalysis of the published literatures on the TNFRⅡ position 196 gene polymorphism and RA. Results  A total of nine literatures involving 2140 cases and 1297 controls were included. Comprehensive analysis showed that there was no association between TNFRⅡ196 alleles, TNFRⅡ196TG, GG genotype and RA, (OR=1.11; 95% CI=0.91-1.34; P=0.32 for TNFRⅡ196 alleles；OR=1.38; 95% CI=0.97-1.98; P=0.07 for TNFRⅡ196TG genotype；and OR=1.09; 95% CI=0.93-1.27; P=0.31 for TNFRⅡ196GG genotype. However, an association between TNFRⅡ196 alleles and TNFRⅡ196GG genotype and familial RA was found (OR=1.43; 95% CI= 1.11-1.86; P=0.006 for TNFRⅡ196 alleles and OR=2.68; 95% CI=1.39-5.17; P=0.003 TNFRⅡ196GG genotype, respectively), but not between TNFRⅡ196TG genotype and familial RA (OR=1.00; 95% CI=0.71-1.39; P=0.98). Finally we found no association between the TNFRⅡ196 alleles, TNFRⅡ196GG, TG genotype and Sporadic RA (OR=1.13; 95% CI=0.891.44; P=0.32 for TNFRⅡ196 alleles; OR=1.44; 95% CI= 0.75-2.76; P=0.27 for TNFRⅡ196GG genotype; and OR=1.03; 95% CI=0.76-1.39; P=0.86 for TNFRⅡ196TG genotype). Conclusions  This Meta-analysis suggested that there was no association between the TNFR Ⅱposition 196 gene polymorphism and RA, but the TNFRⅡ196 alleles and the GG genotype might be associated with familial not sporadic RA.

Key words: arthritis, rheumatoid; Polymorphism(genetics); Tumor necrosis factor Receptor Ⅱ; Meta analysis