Abstract:

Objective  To detect the expression of Stathmin in laryngeal papilloma(LP) and polyp of vocal cord and to explore its role in the development of LP. Methods  Immunohistochemical (PV-9000 two-step method) method was used to analyze the protein expression of Stathmin in paraffin embedded tissues from 60 cases of laryngeal papilloma and 15 cases of vocal cord polyp. Image-ProPlus software was used to determine the average optical density (MOD) of immunohistochemical image，and the relation between MOD and clinical feature of LP was analyzed. Results  The positive expression rate of Stathmin protein in LP tissues ( 88.33%) was higher than in polyp of vocal cord（53.33％）, and the difference was significant(P＜0.05). The expression of Stathmin protein had no relations with clinical type, disease relapse, sex and age of patients (P＞0.05). Conclusion  The high expression of Stathmin protein in LP tissues may be closely related to the occurrence and development of human LP.

Key words: Laryngeal papilloma；Stathmin；Immunohistochemistry