Abstract:

Objective  To study the intervention effects of diet-control, aerobic training and rosiglitazone on cardiac interstitial remodeling in high fat-fed obese rats. Methods  SD rats were randomly divided into the normal control group and the high fat-fed group, which were fed with a basic and high fat diet respectively for 8 weeks. High fat-fed obese rats were selected according to their body weight and then divided into obese control group, diet-control group, diet-control plus swimming group and diet-control plus rosiglitazone group. Cardiac structure, serum lipids levels, serum PAI-1 levels, cardiac collagen contents and PAI-1 mRNA expressions were measured at the 16th week. Results  Cardiac collagen contents and PAI-1 levels in serum and hearts were increased in high fat-fed obese rats with hypertrophic left ventricle(P＜0.05,P＜0.01). Cardiac structure, collagen accumulation and PAI-1 mRNA expressions were improved in diet-control group(P＜0.01). Left ventricular hypertrophy was aggravated and PAI-1 expressions were decreased markedly in diet-control plus swimming group(P＜0.01). Cardiac collagen contents and PAI-1 levels in serum and hearts were decreased significantly in diet-control plus rosiglitazone group(P＜0.05,P＜0.01) with remarkably rehabilitated cardiac structure. Conclusion  PAI-1 might be related to cardiac interstitial remodeling in high fat-fed obese rats. Diet-control, aerobic training and rosiglitazone therapy could improve cardiac remodeling in various degrees.

Key words: Interventional studies; Obesity; Cardiac remodeling; Plasma plasminogen activator inhibitors; Rats