JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (5): 1-4.

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Levels of serum pancreatic derived factor（PANDER）and their correlations with islet β cell function in newly diagnosed type 2 diabetic patients

ZHUANG Feng1, GUAN Qingbo1, GAO Ling1, YU Chunxiao1, TIAN Limin1,
 WANG Jing2, FAN Youfei1, DU Dongdong3, ZHAO Jiajun1   

  1. 1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;
    2. Jinan Fourth People′s Hospital, Jinan 250031, China;
    　3. Department of Clinical Laboratory, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2010-01-04 Online:2010-05-16 Published:2010-05-16

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Abstract:

Objective  To determinate the levels of serum pancreatic derived factor (PANDER) in newly diagnosed type 2 diabetic patients and to investigate the relationship between islet β cell function, insulin resistance and serum PANDER.  Methods  Oral glucose tolerance and insulin releasing test was performed in 36 newly diagnosed type 2 diabetic patients(T2DM group) and 23 healthy people(NC group). Differences of parameter for blood glucose, insulin, islet β cell function and insulin resistance were compared between the two groups，and the correlation between islet β cell function, insulin resistance and PANDER was analyzed.  Results  Serum PANDER levels in T2DM group were higher than those in NC group(P＜0.01)；serum PANDER was independently positively correlated with islet β cell function(P＜0.05)，but was not correlated with insulin resistance(P＞0.05).  Conclusion  PANDER may be a novel serum inflammation marker, and take part in the pathogenesis of T2DM.

Key words: Type 2 diabetes; Pancreatic derived factor; Islet β cell function

CLC Number: 

  • R587.1
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