两种剂量肾上腺素在家猪长时程室颤心肺复苏中的疗效比较

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (4): 32-35.

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Comparison of the effects of two doses of epinephrine during cardiopulmonary resuscitation in a swine model of prolonged ventricular fibrillation

MENG Xianglin, ZHONG Jingquan, SU Guoying, ZENG Qixian, LIU Hongzhen， LIU Donglin, WANG Yuanlong, LI Jingsha, ZHANG Yun

Department of Cardiology，Qilu Hospital of Shandong University， Jinan 250012， China

Received:2009-10-12 Online:2010-04-16 Published:2010-04-16

Abstract

Abstract:

Objective To compare the effects of two doses of epinephrine in a swine model of pronged ventricular fibrillation. Methods Sixteen domestic swine were randomly divided into two groups and received a standard dose of epinephrine (Sepi-gro, 0.02mg/kg) or a high dose of epinephrine (Hepi-gro, 0.1mg/kg) . Ventricular fibrillation (VF) was electrically induced and sustained for eight minutes. Then 2 minutes of cardiopulmonary resuscitation, shock and epinephrine were successively given. Hemodynamics and restoration of spontaneous circulation（ROSC) were observed. Results ROSC rates were identical in both groups. Hemodynamics and successful defibrillation rate had no significant differences between the two groups. Conclusion A high dose of Epinephrine does not i
mprove hemodynamics, ROSC rate and successful defibrillation rate.

Key words: Epinephrine; Prolonged ventricular fibrillation; Cardiopulmonary resuscitation

CLC Number:

R605.97

MENG Xianglin, ZHONG Jingquan, SU Guoying, ZENG Qixian, LIU Hongzhen，LIU Donglin, WANG Yuanlong, LI Jingsha, ZHANG Yun . Comparison of the effects of two doses of epinephrine during cardiopulmonary resuscitation in a swine model of prolonged ventricular fibrillation[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(4): 32-35.