JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (4): 27-.

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Effect of Qindan Capsule on arterial adventitial fibroblasts

REN Min1, ZHANG Jidong1, WANG Bo1，　LIU Ping2，　JIANG Hong3，　LIU Guilin1   

  1. 1. Department of Traditional Chinese Medicine， Qilu Hospital of Shandong University, Jinan 250012, China；
    2. Department of Health Management, Second Hospital of Shandong University, Jinan 250033, China；
    3. Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2009-11-17 Online:2010-04-16 Published:2010-04-16

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Abstract:

Objective  To investigate the effect and mechanism of the Qindan Capsule-containing serum on adventitial fibroblasts(AFs). Methods  AFs were cultured by tissue explant in vitro and induced by TGF-β1. The proliferation of AFs affected by the Qindan Capsule-containing serum with high［750mg/（kg·d）］ or low［150mg/（kg·d）］ dose was detected by MTT. Protein and mRNA expressions of α-SM actin and Smad3 were observed by Western-blot and Real-time PCR respectively. Results  Both high and low doses of the Qindan Capsule-containing serum could reduce proliferation of AFs induced by TGF-β1（P＜0.05） and inhibit expressions of mRNA and protein of α-SM actin and Smad3（P＜0.05）. Conclusion  The Qindan Capsule-containing serum has significant improved and reverse effect on aortic vascular remodeling. The mechanism may be related to inhibiting  proliferation and differentiation of AFs through the  TGF-β1/Smad signaling pathway.

Key words: Qindan Capsule; Transforming growth factor-beta1/Smad; Adventitial fibroblast; Proliferation; Rats

CLC Number: 

  • R543.5
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