Abstract:

Objective  To study the effect of the big Y chromosome on in vitro fertilization embryo transfer outcome. Methods  Patients who completed in vitro fertilization fresh embryo transfer cycles at Reproductive Medical Center of Provincial Hospital Affiliated to Shandong University from January 2006 to December 2008 were selected. In the big Y group (33 patients, 47 treatment cycles), the male chromosome of the patients was a big Y of G banding and  their wives had no diseases which might influence the outcome of in vitro fertilizationembryo transfer. In the control group, all the other 6620 treatment cycles at the same period were involved. Results  There was no significant difference between the big Y group and the control group in  fertilization rate, cleavage rate, good-quality embryo rate, embryo imbed rate, pregnancy rate and early abortion rate（P＞0.05）, but the ratios of deformed babies and females at  birth were higher in the big Y group(P＜0.05). Conclusion  In conventional in vitro fertilization and embryo transfer cycles, there is no significant difference in embryonic development and recent pregnancy outcome between patients with the big Y chromosome  and  normal patients. Women whose husbands have big Y chromosomes undergoing  conventional in vitro fertilization embryo transfer cycles are more likely to give birth to girls.

Key words: Chromosome polymorphism; Chromosome, human, 2122 and Y; In vitro fertilization; Recurrent abortion