Abstract:

Objective    To investigate the dynamic fluctuation of fibrinolytic activity in hypertensive intra-cerebral hemorrhage patients with minimally invasive surgery(MIS). Methods     Blood samples were obtained on days 1, 3, 7 and 14 after onset from 46 patients with MIS and 43 patients with non-minimally invasive surgery, 48 normal subjects were controls. Levels of plasminogen activator inhibitor-1 (PAI-1) antigen and tissue-type plasminogen activator (t-PA) were measured with enzyme linked immunosorbent assay (ELISA). Results     Level of t-PA in the MIS group on days 1, 3 and 7 after onset was significantly higher than that in the control group (P<0.05), while there was no significant difference between the MIS group and the control group on day 14. Level of PAI -1 in the MIS group on days 3 and 7 was significantly higher than that in the control group ( P<0.05). Level of tPA in the MIS group on days 3 and 7 was significantly lower than that in the non-minimally invasive surgery group (P<0.05), while level of PAI-1 in the MIS group on days 3 and 7 was significantly higher than that in the non-minimally invasive surgery group (P<0.05). Levels of t-PA and PAI-1 in the MIS group on days 1, 3 and 7 had a correlation with the National Institutes of Health Stroke Scale (NIHSS). Conclusion      A fluctuation regularity exists in fibrinolytic activity in hypertensive intracerebral hemorrhage patients with MIS. Levels of t-PA and PAI-1 can be used as biomarkers for clinical outcomes in patients with MIS.

Key words: Intracranial hemorrhage, hypertensive; Plasminogen activators; Plasminogen inactivators; Minimally invasive surgery