JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (10): 20-.

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Mechanism of reversal of cardiac fibrosis in fructosefed rats by Felodipine

XING Shan-shan1,2, TAN Hong-wei1, BI Xiu-ping1,3, ZHONG Ming1,  ZHANG Yun1, ZHANG Wei1   

  1. 1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Ministry of 
    Public Health; Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China;
    2. Shandong University of Traditional Chinese Medicine, Jinan 250355, China;
    3. Department of Cardiology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China
  • Received:2010-07-16 Online:2010-10-16 Published:2010-10-16

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Abstract:

Objective    To investigate the mechanism of reversal of cardiac fibrosis in fructose-fed rats (FFRs) by Felodipine. Methods    Thirty-three male Wistar rats were randomly divided into the control group (n=12) and the metabolic syndrome (MS) group (n=21). After the MS model was built by feeding with 10% fructose water for 8 months, 9 FFRs were perfused into the stomach with Felodipine once daily. Then, myocardium tissues were collected. Collagen content was detected by Sirius Red staining and real-time RT-PCR was to detect mRNA expression of interleukin-18(IL-18). Results    The collagen content of MS group was significantly higher than that of the control group (P<0.01).  mRNA expression of IL-18 was significantly higher in the MS group than in the control group (P<0.01). After six-week treatment of Felodipine, the collagen content and IL18 mRNA expression were significantly lower than those in the MS group. Conclusion    Felodipine ameliorates cardiac fibrosis in MS via its suppressive effect on IL18 expression.

Key words: Metabolic syndrome; Models, animal; Cardiac fibrosis; Interleukin-18; Rats, Wistar

CLC Number: 

  • R542.2
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