Abstract:

Objective     To observe the efficacy of narrowband-ultraviolet B (NB-UVB) combined with interferon α-2b in the treatment of mycosis fungoides (MF) patients and evaluate the effects of the procedures on serum CCL27 level. Methods      Seventeen patients with MF were treated with NB-UVB combined with interferon α-2b. Patient′s sera were collected before and after treatment. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum CCL27 level. The control group consisted of sixteen healthy subjects. Results      Serum CCL27 level of MF patients was significantly higher than that of the control group（P＜0.01）. The rate of complete clinical remission (CCR), partial clinical remission (PCR) and  total response rate (CCR+PCR) were 64.71%, 29.41%, and 94.12%, respectively. Serum CCL27 level significantly decreased after the combined treatment（P＜0.01）. Conclusion     NB-UVB combined with interferon α-2b in the treatment of  MF patients is an effective and safe therapy which can decrease the serum CCL27 level.

Key words: Mycosis fungoides; Interferon α-2b; Ultraviolet B; Narrowband; CCL27