Abstract:

Objective  To determine plasma omentin-1 and visfatin levels of newly diagnosed type 2 diabetes patients and type 2 diabetes patients with artery atheromatous plaques, and to explore the relationship between plasma omentin-1,visfatin level and diabetes with atherosclerosis. Methods  66 newly diagnosed type2 diabetes subjects were divided into the artery atheromatous plaques group(AAP group, n=34) and the no artery atheromatous plaques group(nAAP group, n=32)by artery ultrasonography of the carotid,　femoral and iliac artery.　Another 32 healthy subjects were included as normal controls. ELISA technique was used to determine plasma omentin-1 and visfatin，　and demographic and metabolic indicators were detected in the three groups.Statistical analysis was used to reveal the relationship between plasma omentin-1,visfatin level and diabetes with atherosclerosis. Results  The concentration of plasma omentin-1 was decreased and visfatin was increased in the type 2 diabetes mellitus group compared with those in the control group(P＜0.05), and the concentration of plasma omentin-1 was decreased in the AAP group compared with that in the nAAP group(P＜0.05), but the difference of the concentration of plasma visfatin between the AAP  group and the nAAP group was not significant（P＞0.05）. Plasma omentin-1 level was negatively correlated with low density lipoprotein cholesterol,wight,body mass index,waist circumference,　hip circumference and the natural logarithm of fasting blood glucose(P＜0.05). Plasma visfatin level was positively correlated with age, the natural logarithm of fasting insulin,　low density lipoprotein cholesterol,　the natural logarithm of insulin resistance indexand the natural logarithm of fasting blood glucose（P＜0.05）. Conclusion  Plasma omentin-1 and visfatin are closely related to type 2 diabetes mellitus and plasma omentin-1 is significantly related to the occurrence and development of  the atherosclerosis of early type 2 diabetes mellitus.

Key words: Artery atheromatous plague； Type 2 diabetes mellitus； Omentin-1； Visfatin