Abstract:

Objective  To study serum oxidation level andneurological injury in cerebral ischemia reperfusion rats and the influences of propofol on them. Methods   Eighty-eight rats were randomly divided into three groups:the sham operation group（n=8）, the cerebral ischemia reperfusion model group(n=40) and the propofol(100?mg/kg) group(n=40).  Cerebral ischemia reperfusion models were established inSDrats by middle cerebral artery occlusion (MCAO) according to the advanced Zea Longa′s method. The neurological deficit score of the rats,infarct area of the brain and levels of SOD and MDA in serum were measured with absorption spectrometry at 6h, 24h, 2d, 4d and 7?d after reperfusion.Results  Compared with the model group, the propofol group decreased in the infarct area of the brain. The neurological function deficit score at 24?h or 2?d after reperfusion was also significantly lower(P＜0.05) in the propofol group. At the same time, the serum MDA level decreased while SOD activity increased in the propofol group(P＜0.05). Conclusions   MDA increases while SOD activity decreases after cerebral ischemia reperfusion. Propofol can effectively suppress the production of lipid peroxidation and MDA, facilitate the production of SOD and decrease the infarct area of the brain,so it reduces neurological injury induced by ischemia and reperfusion.

Key words: Propofol； Cerebral ischemia and reperfusion injury； Antioxidant； Neurological function deficit score； Model；Animal