JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (1): 34-37.

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Expressions of bFGF in rabbits′ periodontium under  different orthodontic forces

ZHANG Liao1, ZHUGE Chungeng1, MEI Yinsheng2, ZHANG Jun2   

  1. 1. Hospital of Stomatology of Taian, Taian 271000, Shandong, China; 
    2. Department of Orthodontics, College of Stomatology, Shandong University, Jinan 250012, China
  • Received:2009-02-23 Online:2010-01-16 Published:2010-01-16

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Abstract:

Objective  To research expression and distribution of basic fibroblast growth factor (bFGF) in periodontium by establishing orthodontic tooth movement model of rabbits and to analyze the role of bFGF in orthodontic tooth movement. Methods  The orthodontic tooth movement model of rabbits was established. [JP2]10g, 50g and 100g forces were respectively exerted on the three experimental groups until the animals were executed one week later. Then, the first molar and periodontium specimens were taken out, and immunohistochemical staining (HI-SABC method) was performed and the results were compared. Results  The staining result of  the control group was weakly positive. A significant difference was only found between the 50g force group and the control group among the multiple comparisons. Conclusion  Suitable orthodontic force could enhance expression of bFGF in  the periodontium. bFGF may participate in orthodontic tooth movement and promote the repairing and rebuilding of the periodontium.

Key words: Fibroblast growth factors; Periodontium; Orthodontic force; Rabbits

CLC Number: 

  • R783.5
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