Abstract:

Objective  To explore the effect of penehyclidine hydrochloride on cardiovascular injury caused by hydrogen sulfide. Method  32 cases were divided into two groups(16 cases in each group). The control group underwent routine treatment, and the other group was treated by both penehyclidine hydrochloride and routine treatment. The serum myocardiac enzyme was determined at 30min, 24h, 3d and 7d, and the levels of TNF-α and IL-8 were determined at the above time points by ELISA. Results  Compared with the control group, the levels of myocardiac enzyme and the plasma TNF-α and IL-8 significantly decreased. And by ECG,  the impairedST and T wave were significantly improved. Conclusion  Penehyclidine hydrochloridehas a protective effect on cardiovascular injury induced by hydrogen sulfide and improves cardiovascular function.

Key words: Penehyclidine Hydrochloride; Hydrogen Sulfide; Acutepoisoning; Cardiovascular injury