Abstract:

Objective  To evaluate the clinical value of osteoprotegerin（OPG） in predicting coronary artery lesions(CAL) of Kawasaki disease(KD). Methods   90KD patients(KD group), 30 febrile patients with infective diseases( fever group), 20 patients with sytemic lupus erythematousus(SLE group) and 30 healthy children(control group) were included in this study.  Blood samples were collected for routine laboratory tests, including erythrocyte sedimentation rate （ESR）, C-reactive protein (CRP), white blood cell count(WBC), hemoglobin(HB), platelet count (PLT), serum albumin(ALB) and OPG concentration. The severity of coronary arterylesions was determined by the diameter of the involved coronary artery. Multivariate logistic regression was used to find risk factors of CAL. A receiver operatingcharacteristic curve (ROC) was established to confirm the diagnostic value of the risk factors.  Results  Serum OPG level of the KD group is higher than that in the fever group, SLE group and control group(P＜0.05). Serum OPG and CRPlevel is significantly higher in KD patients with CAL than those without CAL(P＜0.05), and serum ALB level was lower(P＜0.05). Multivariate logistic regression results showed that OPG, CRP and ALB were risk factors of CAL in KD patients. Serum OPG, CRP and ALB levels of patients with acute KD were all reliable indicators to predict CAL development by ROC analysis(P＜0.05).  Conclusion  Serum OPG is an independent risk factor of CAL for patients with KD, and may help to predict CAL in the acute phase of KD.

Key words: Kawasaki disease; Osteoprotegerin; Coronary artery lesion; Risk factors; Echocardiogram