Abstract:

Objective  To probe into the effect of mifepirstone on expression of nuclear factor-κB（NF-κB） in human villi during the early pregnancy. Methods  Expression of NF-κB was detected in human villi of 18 surgical abortion women and 22 medical abortion women by RT-PCR and immunohistochemical analysis. Results  Expression of NF-κB mRNA in villi of the medical abortion group was significantly weaker when compared with that of the surgical abortion group(P＜0.01)，and expression of NF-κB protein in cytotrophoblasts of the medical abortion group was significantly weaker when compared with that of the surgical abortion group(P＜0.05). Conclusions  Decreased expression of NF-κB in human villi induced by mifepristone may be one of the mechanisms for terminating early pregnancy.

Key words: Nuclear factor-κB； Villi； Cytotrophoblasts； Mifepristone； Villous stromal