Abstract:

ObjectiveTo explore cardiac toxicity in rats exposed to aluminum chloride (AlCl3), and to evaluate the protection of 1,2dimethyl3hydroxy4pyridone (DFP) against toxicity. Methods35 male Wistar rats were divided into five groups by weight. Four groups except for the negative control group were administered aluminum chloride (172.5?mg/(kg·d)) for 8 weeks, then  different dosages of DFP were given for 2 weeks. Activity of LDH, CK and  AST in the serum,  activity of TSOD and GSHPx and  content of essential elements were determined.1 Results Activity of LDH and CK in the serum and  content of MDA in the aluminum group were significantly higher than those in the negative control group (P<0.01).  Activity of GSHPx. and  content of Fe in the cardiac muscle of the Al group were significantly lower than those in the negative group (P<0.01, P<0.05). However, activity of LDH and CK in the DFP group was significantly lower than that in the Al group (P<0.01). Content of Fe in the DFP group was significantly higher than that in the Al group (P<0.05), while there were no significant differences between groups of Zn, Mg, Cu and Ca in cardiac muscle. ConclusionAlCl3 can induce myocardial damage, while  DFP can protect the myocardial  muscle against damage.

Key words: Aluminum; 1,2dimethyl3hydroxy4pyridone; Myocardium zymogram; Lipid peroxidantion; Essential elements; Rats, Wistar