JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (7): 125-132.

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Prediction of HBV multiepitope vaccines based on GIS in the population of China

XUE Hao 1, ZHANG Yingqian 1, XUE Fuzhong 2, MA Chunhong 1   

  1. 1. Institute of Immunology, School of Medicine; 2. School of Public Health, Shandong University, Jinan 250012, China
  • Received:2008-11-24 Published:2009-07-16

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Abstract:

To predict the theoretical responder status of HBV multiepitope vaccines in the Chinese population and to provide guidance for preparation and research of HBV multiepitope vaccines.　MethodsCumulative phenotypic frequency (CPF) of HBV multiepitope vaccines was calculated using Forecasting System of Theoretical Immune Response Rate of HLAAB Loci Restricted Multiepitope Vaccine in Chinese Population, and thus the theoretical responder status in the Chinese population was evaluated. ResultsThe theoretical responder status of HBV multiepitope vaccines whose HLAI restricted epitopes belonging to one supertype was low and belonging to different supertypes was comparatively high in the Chinese population.  ConclusionThis research predicts the theoretical responder status of HBV multiepitope vaccines in the Chinese population. This helps to evaluate effects of vaccines with different combinations of HLAI restricted epitopes and shows new directions of HBV multiepitope vaccines.

Key words: Hepatitis B; Multiepitope vaccine; DNA vaccines; Spatial forecasting system; Cumulative phenotypic frequency of HLAⅠHBV

CLC Number: 

  • R512.6
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