Abstract:

To explore the relationship between SERPINE2 polymorphisms and chronic obstructive pulmonary  disease（ COPD）related phenotypes and to investigate the mechanism of COPD. Methods100 patients with COPD served as the experimental group and 100 healthy people as the control group. In the present study, we genotyped the single nucleotide polymorphisms (SNPs) from SERPINE2 by special allele multiprobe technology and identified its gene type. The casecontrol data were analyzed using a chisquare test and correlation analysis. ResultSNP rs6734100 had no significant association with COPD.  ConclusionSERPINE2 is not a COPD susceptibility gene in the Han population.

Key words: Pulmonary disease， chronic obstructive； Serine proteinase inhibitors； Polymorphism, single nucleotide