JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (11): 74-75.

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Effects of the Rosiglitazone on expressions of MMP2 and TIMP1 mRNA in hepatic stellate cells

LI Senlin, ZHAO Jingrun, REN Xiaoyan, MA Qingzhu, XIE Jiaping, LI Zhenfang, LANG Cuicui   

  1. Department of Digestive Disease, Liaocheng People′s Hospital,  Liaocheng 252000, Shandong, China
  • Received:2009-09-15 Published:2009-11-16

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Abstract:

To investigate the effects of Rosiglitazone on expressions of MMP2 and TIMP1 mRNA in hepatic stellate cells (HSCs) in vitro. MethodsThe HSC line, HSCT6 was incubated with different concentrations of Rosiglitazone. The MMP2 and TIMP1 mRNA levels were measured by reverse transcription polymerase chain reaction (RTPCR).  ResultsExpression of TIMP1 mRNA in the Rosiglitazonetreatment groups was significantly lower than that in the control group (P＜0.05), and there was no difference in the MMP2 mRNA levels between the Rosiglitazonetreatment groups and the control group. ConclusionThe antifibrosis mechanism of Rosiglitazone is partly due to its downregulation on TIMP1 but not on MMP2 expression of hepatic stellate cells.

Key words: Rosiglitazone; Hepatic stellate cells; Matrix metalloproteinases2; Tissue inhibitor of metalloproteinases

CLC Number: 

  • R575
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