JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (11): 128-131.

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Mixed micelles made of Pluronic P105 and L61 as pharmaceutical  nanocarriers for camptothecin

SUN Xintang， WANG Jinli，  LI Lingbing   

  1. Department of Pharmaceutics, School of Pharmacy, Shandong University, Jinan 250012, China
  • Received:2009-04-24 Published:2009-11-16

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Abstract:

To increase the drug loading of the poorly soluble anticancer drug, camptothecin (CPT)， micelles made of a mixture of Pluronic P105 (P105) and Pluronic L61 (L61) were prepared. MethodsMixed micelles made of a mixture of Pluronic P105 (P105) and Pluronic L61 (L61) were prepared loaded with CPT. The drug loading and colloidal stability of such systems were studied, and cytotoxicity of the CPTloaded mixed micelles against MCF7 cancer cells in vitro was determined. ResultsThe CPTloaded mixed micelles were stable upon storage and dilution. Drug loading of CPT was increased with an increase of the amount of Pluronic L61. Cytotoxicity of the CPTloaded mixed micelles against MCF7 cancer cells in vitro was remarkably higher than that of the free drug. ConclusionMixed micelles made of a mixture of Pluronic P105 (P105) and Pluronic L61 (L61) may serve as a stable delivery system for poorly soluble CPT.

Key words: Pluronic micelles; Camptothecin; Cytotoxicity

CLC Number: 

  • R944.9
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