JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (11): 124-127.

• Articles • Previous Articles     Next Articles

Uncertainty of the content of Glibenclamide in Chinese Traditional Medicine determined by HPLC

LING Xiao 1 , XIE Fei 2 , WU Jingde 3   

  1. 1. Shandong Provincial Institute for Drug Control, Jinan 250101, China; 
    2. Marine College, Shandong University at Weihai,  Weihai 264209, Shandong, China;
    3. Department of Organic Chemistry,School of Pharmacy, Shandong University, Jinan 250012, China
  • Received:2009-03-09 Published:2009-11-16

Abstract:

To establish a method for evaluation of uncertainty of determination of glibenclamide illegally added in Jiangtangning by HPLC. MethodsThe uncertainty was evaluated by a established mathematical model and various factors affecting sample detection were analyzed. ResultsUncertainty of each componet was calculated and their combined uncertainty was then finally obtained by synthesizing the uncertainties of various component variables. ConclusionThis method is appropriate to be used in uncertainty evaluation for determination of declofenac sodium in Chinese traditional medicine by HPLC.

Key words:  High performance liquid chromatography; Glibenclamide; Uncertainty

CLC Number: 

  • R73941
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