Abstract:

 To study the risk factors of contrastinduced nephropathy(CIN)in patients undergoing coronary artery angiography and/or percutaneous coronary intervention(PCI). Methods200 patients undergoing PCI or coronary angiograph from October 2008 to March 2009 were enrolled in this study. Levels of serum creatinine, blood urine nitrogen and urine β2microglobulin were determined three days before and at 3, 7 days after coronary artery intervention. ResultAmong the 200 patients, 14 patients(7%) developed CIN.The incidence of preexisting renal dysfunction, hypertension, diabetes mellitus in CIN patients and in nonCIN patients did not significantly vary(P＜0.05). Age, body mass index(BMI), angiotensin converting enzyme inhibitors (ACEIs),　coronary arteriosclerosis, dosages of contrast agent and hyperlipemia  did not significantly vary between the two groups (P＞0.05). Identified by regression, preexisting renal dysfunction and diabetes mellitus were independent risk factors of CIN. ConclusionsHypertension is one related risk factor of CIN, while age, BMI, ACEIs, coronary arteriosclerosis, dosages of contrast agent and hyperlipemia are not. Preexisting renal dysfunction and diabetes mellitus are independent risk factors of CIN.

Key words: Coronary artery angiography; Percutaneous coronary intervention; Contrastinduced nephropathy; Risk factors