Abstract:

To investigate the factors affecting large arterial stiffness in patients with continuous ambulatory peritoneal dialysis (CAPD)． MethodsClinical stable CAPD patients (n=241) in a single center were enrolled in this study. Carotidfemoral PWV was measured with a validated automatic device and was used as an index for large arterial stiffness. The volume load was evaluated by a body composition monitor (BCM). In addition， biochemical indices,such as blood pressure, serum uric acid, albumin， Creactive protein, serum creatinine， serum triglycerides， and total cholesterol lipoprotein were determined with standard methods. Pearson′s correlation and multiple regression analysis were performed to identify the relationship between related factors and PWV.  ResultsPWV was strongly associated with diabetic mellitus (DM)， age， uric acid，  systolic blood pressure(SBP), pulse pressure, albumin, and extracellular water normalized by height. Multiple regression analysis showed that PWV was independently determined by DM［（1Yes，0No）(β=0.307，P=0．001),age（β=0．329， P=0．001),　uric acid（β=0．274，P=0．001),　systolic blood  pressure (SBP)（β=0．188，　P=0．002)　and dialysis duration　（β=0.129，P=0.027）. They accounted for 66.3％ of the total variance. ConclusionBesides DM， age and SBP， uric acid and dialysis duration are independent determinants of large arterial stiffness as well in CAPD patients.

Key words: Arterial stiffness; Pulse wave velocity; Uric acid; Peritoneal dialysis