JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (10): 114-117.

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Valuation of theoretical immune response status of HBV multiepitope 
vaccines in existence in the population of China

XUE Hao1, ZHANG Yingqian1, XUE Fuzhong2, MA Chunhong1   

  1. 1. Institute of Immunology, School of Medicine; 2. School of Public Health, Shandong University, Jinan 250012, China
  • Received:2008-11-17 Online:2009-10-16 Published:2009-10-16

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Abstract:

To predict the theoretical immune response status of HBV multiepitope vaccines and valuate its effect in the population of China.　MethodsCumulative phenotypic frequency (CPF) of HBV multiepitope vaccines was calculated by the system, Forecasting System of Theoretical Immune Response Rate of HLAAB Loci Restricted Multiepitope Vaccine in the Chinese Population, and thus their theoretical responder status in the Chinese population was evaluated.　ResultsThe problems of HBV multiepitope vaccines had already been found in the two aspects. On the one hand, the theoretical responder status of most HBV multiepitope vaccines are low in the Chinese population, on the other hand, vaccines with high theoretical responder status are combinations of five or more epitopes, which is unnecessary and uneconomical.  ConclusionHBV multiepitope vaccines have already been observed do not achieve the ideal level, and new HBV multiepitope vaccines should be worked on.

Key words: Hepatitis B; Multiepitope Vaccine; DNA vaccines; Spatial forecasting system; Cumulative phenotypic frequency of HLA

CLC Number: 

  • R512.6
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