Abstract:

To explore the relationship between an ALOX15′s polymorphism, rs916055 T＞C, and coronary heart disease (CHD) in the Chinese Han population from Shandong Province. MethodsA total of 452 unrelated CHD patients and 507 unrelated control subjects were recruited in a casecontrol study. The genotypes of rs916055 T＞C were performed by polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP). ResultsNo significant deviation from the HardyWeinberg equilibrium was found in the polymorphism in the CHD or control groups. There was no significant difference in frequencies of allele and genotype in rs916055 T＞C between the CHD and control groups. After adjusting for other potential confounders including age, gender, BMI, SBP, DBP, Glucose, TG, TC, HDLC and LDLC, there was a significant difference in the genotype frequencies of rs916055 T＞C between the two groups, and the carriers of the C allele (CC+CT) of rs916055 T＞C had a significantly higher susceptibility to CHD than the TT homozygotes (OR=3.480, 95% CI:1.14310.592, P=0.028). No association was found between the severity of CHD and rs916055 T＞C. Conclusionrs916055 T＞C of ALOX15 is associated with the susceptibility of CHD in this Chinese Han population from Shandong Province.

Key words: Arachidonate 15Lipoxygenase; Coronary artery diseases; Polymorphism, single nucleotide