JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Influence of curcumin on structure and function of kidney in diabetic rats

YU Dongqing1, LIU Jinbo2，　DENG Huacong3
   

  1. (1. Intensive Care Unit, Shandong Provincial Hospital, Shandong University, Jinan 250021, China;
    2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China;
    3. Department of Endocrinology, First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016, China)
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16

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Abstract: To explore the effect of curcumin on the structure and function of the kidney in diabetic rats. MethodsDiabetes was induced by a single intraperitoneal injection of streptozoticin(STZ) to male Wistar rats at a dose of 60?mg/kg body weight and they were randomly divided into two groups: the diabetes group (group D) and the diabetes treated with curcumin group(group DC). A normal control group (group N) was also designed. Curcumin was given at a dose of 200?mg·kg-1·day-1, the other two groups were given the same quantity of CarboxylmethylCellulose(CMC). After a treatment of 8 weeks, renal morphology and blood and urinary biochemistry were evaluated. ResultsLevels of clearance of creatinine(Ccr)， urinary albumin excretion rate(UAER), albumincreatinine ratio(Alb/Cr), mean glomerular area(MGA) and mean glomerular volume(MGV) were all significantly increased in group D as compared with group N(P＜0.01 or P＜0.05) . Large glomeruli，membranes with a thickened glomerular basement, and foot processes confluence into podocytes were found by light microscopy and electron microscopy. All these abnormalities were markedly ameliorated after a curcumin treatment. ConclusionCurcumin is effective in improving renal pathological damage, ameriorating hypertrophy and hyperfiltration, and decreasing the urinary albumin excretion rate(UAER)in diabetic Wistar rats.

Key words: Curcumin, Diabetic mellitus, Wistar rats, Kidney

CLC Number: 

  • R282.71
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