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Effects of RARα and β-catenin on the development of cleft palate induced by excess retinoid acid in KM mice

YIN Hai-yan1， LIU Kai1， ZHANG Yan-ping2, DUAN Shu-hong1   

  1. 1. Department of Histology and Embryology, School of Medicine, Shandong University, Jinan 250012, China;2. Key Laboratory of Birth Health and Heredigy, Shandong Instistute of Fanily Planning, Jinan 250002, China
  • Received:2007-12-28 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: YIN Hai-yan

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Abstract: To explore the effects of RARα and β-catenin on cleft palate induced by excess retinoid acid in KM mice. MethodsIn both malformed embryos induced by excess retinoid acid (the experimental group) and normal KM mice (the control group) the expressions of RARα and β-catenin in the epithelium of palaual shelves and the mesenchyma by immunohistochemistry and image analysis were determined. ResultsThe expression level of RARα in the experimental group was significantly lower than that in the control group, however the expression level of β-catenin were significantly higher in the experimental group than that in the control group. ConclusionThe down-regulated expression of RARα in the epithelium of palatal shelves and the mesenchyma and the up-regulated expression of β-catenin in the epithelium of palatal shelves are closely related to the process of cleft palate induced by excess retinoid acid in KM mice.

Key words: Receptors, retinoic acid, Cleft palate, β-catenin

CLC Number: 

  • R321.6
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