JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expressions of HGF and its receptor in oral squamous cell carcinoma and neck lymph nodes

ZHANG Yan-sheng1，LIU Shao-hua2，WEI Feng-cai2，SUN Shan-zhen1   

  1. Department of Oral and Maxillofacial Surgery， 1. School of Stomatology, Shandong University, Jinan 250012, China；2. Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-09-27 Revised:1900-01-01 Online:2008-04-16 Published:2008-04-16
  • Contact: WEI Feng-cai

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Abstract: To explore the effect of HGF／cMet system on invasive and metastasis potential of oral squamous cell carcinoma (OSCC). MethodsFifty biopsy samples were collected from primary and relapse OSCC patients. Immunohistochemical staining was used to determine the expression of hepatocyte growth factor (HGF) and c-Met protein in OSCC tissues and neck nodes. Samples were divided into groups based on clinicopathological features and then the expression intensity was analyzed between groups. Results The expression rate of HGF and c-Met in carcinoma cells was 100％. The HGF expression rate in neck nodes was 60%. However, c-Met was not expressed in lymphocytes of neck nodes. High expression level of HGF in carcinoma cells and positive expression of c-Met in lymphocytes of neck lymph nodes significantly correlated with lymph nodes metastasis (P=0.0000), and high expression level of HGF had trends to invade (P=0.0020) and relapse(P=0.0139). Conclusion Overexpression of HGF and c-Met in OSCC and positive expression of c-Met in lymphocytes of neck nodes may induce invasion, recurrence and metastasis, predicting a poor prognosis.

Key words: Mouth neoplasms, Lymphatic metastasis, Hepatocyte growth factor, Protooncogene protein c-met

CLC Number: 

  • R739.85
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