Abstract:

Objective To observe the effects of Xuebijing injection on nuclear factor-kappa B activation of PMN and the prognosis of cardiovascular injury.  Methods 70 cases of acute organophosphate poisoning complicated with cardiovascular injury were divided into the positive control group (35 cases)and the test group(35 cases) at random. The enzyme labeled immunohistochemical method was used to determine the NF-κB activation degree. Changes of myocardial enzyme were also observed. Results  ① Death rate of the test group was lower than that of the control group(P＜0.05). ② The NF-κB activation degree of the control group was higher than that of the test group(P＜0.05).　③ Xuebijing injection suppressed the activation of NF-κB on dosage(P＜0.05). ④ The degree of myocardial enzyme recovery of the test group was superior to that of the control group and was dose-dependent on Xuebijing injection(P＜0.05). Conclusion Xuebijing injection in combination with routine therapies has obvious efficiency on increasing the success rate of acute organophosphorus pesticide poisoning patients complicated with cardiovascular injury.

Key words:  Xuebijing Injection; Organophosphate poisoning; Cardiovascular systerm;  Injuries; Immunohistochemistry; Nuclear factor-kappa B